AACE2021-A-1050: Relationship of Serum Level of Bone Formation Biomarker Osteocalcin and CIMT and Metabolic Parameters in Post-Menopausal Females and Type 2 Diabetes

To determine the association between serum levels of OCN and metabolic parameters carotid intima media thickness (CIMT) in a group post-menopausal females with type 2 diabetes (T2DM). This cross-sectional study comprised 75 postmenopausal women T2DM (group 1; 25 patients normal bone mineral density (BMD), 2; osteopenia 3; osteoporosis) 40 age matched non-diabetic females. All subjects included this were subjected to following: thorough clinical evaluation, laboratory investigations including fasting blood glucose (FBG), glycated hemoglobin (HbA1c) lipid profile. Bone (BMD) was measured by DEXA scan. CIMT assessed B-mode ultrasonography. Serum using ELISA. Person’s correlation analysis used evaluate relation different studied population. Multivariate logistic regression model quantitatively analyze interactions. Although there no significant difference control BMD, significantly lower compared (63.73±27.20 vs 136.16±21.96 pg/mL, P<.001). Also, reduction level diabetic osteoporosis as those BMD. In negative (r= -0.332; P=0.003) (fig.1), FBG -0.732; P< 0.001), insulin(r= -0.302; P=0.007), HbA1c -0.672; 0.001) (fig.2), HOMAIR 0.001). Multiple linear showed that insulin (β= -0.183, P=0.033), -0.604, LDL -0.195, P= 0.02) still negatively correlated OCN. concentration is reduced it than Low independent factor associated worse glycemic profile higher resistance conferring thus larger risk developing atherosclerosis patients.